According to the present invention, there is provided an ophthalmic pharmaceutical composition having a specific pH, containing aflibercept as an active ingredient and an acetate buffer, and containing no ionic tonicity agent. The ophthalmic composition of the present invention can significantly reduce the formation of dimer impurities and multimer impurities under high temperature conditions as well as under refrigerated storage conditions and under accelerated conditions and severe conditions, and has high biological activity. It can be maintained at the level for a long time.本発明により、特定のｐＨを有し、活性成分としてのアフリベルセプトと、酢酸塩緩衝剤とを含み、イオン性等張化剤を含まない眼科用医薬組成物が提供される。本発明の眼科用組成物は、冷蔵保管条件下のみならず、加速条件下および苛酷条件下でも、二量体不純物および多量体不純物の生成を著しく減少させることができ、生物学的活性を高いレベルで長期間維持することができる。
