Described herein are oral care compositions comprising an effective amount of an enzyme cocktail, wherein the enzyme cocktail comprises an alkaline protease and a second enzyme selected from cellulase, α-glucanase, and combinations thereof, in an orally acceptable carrier, together with methods of making and using the same.文中係描述包括一有效量之酵素混合物的口腔保健組成物,其中該酵素混合物係於口腔可接受的載劑中包括一鹼性蛋白酶和選自纖維素酶、α-聚葡萄糖酶及其組合物之第二酵素,以及彼等之製造和使用方法。