UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;UNIVERSITY OF SOUTH FLORIDA
发明人:
Mildred Enid ACEVEDO-DUNCAN,Wishrawana Sarathi RATNAYAKE,David A. OSTROV
申请号：
US16554187
公开号：
US20200022994A1
申请日:
2019.08.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention pertains to a method of treating melanoma by administering to a subject in need thereof, a composition comprising a therapeutically effective amount of an inhibitor of PKC-ζ and/or PKC-ι. Non-limiting examples of an inhibitor of PKC-ζ and/or PKC-ι include ICA-1 and ACPD. The invention also provides PKC-ζ and/or PKC-ι as biomarkers for identifying a melanoma in a subject as likely to be responsive or non-responsive to a therapy using an inhibitor of PKC-ζ and/or PKC-ι. Accordingly, a method of identifying a subject having a melanoma as being responsive or non-responsive to a melanoma therapy with an inhibitor of PKC-ζ and/or PKC-ι based on the levels and/or activity of PKC-ζ and/or PKC-ι mRNA or protein in the melanoma cells from the subject are also provided.
