Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease

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专利权人:

Leslie P. Weiner

发明人:

Leslie P. Weiner,Minnie McMillan

申请号：

US11488524

公开号：

US08323963B2

申请日:

2006.07.17

申请国别(地区):

US

年份:

2012

代理人:

摘要：

This invention relates to the design and construction of a gene encoding an encephalogenic epitope of proteolipid protein (PLP), design and construction of a gene encoding an encephalogenic epitope of myelin based protein (MBP), to methods of expression of a PLP epitope, to methods of expression of a MBP epitope, to methods of in vivo secretion of a PLP epitope, and to methods of transferring the partial PLP gene to a host to ameliorate the progression of an immune response to self antigens derived from myelin proteins, to methods of in vivo secretion of a MBP epitope, and to methods of transferring the partial MBP gene to a host to ameliorate the progression of an immune response to self antigens derived from myelin proteins.

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中国工程科技知识中心

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http://www.ckcest.cn/home/