UNIVERSITY OF KANSAS;BLAGG, BRIAN, S. J.;DUERFELDT, ADAM, S.
发明人:
BLAGG, BRIAN, S. J.,DUERFELDT, ADAM, S.
申请号：
WO2012US32538
公开号：
WO2012139010(A1)
申请日:
2012.04.06
申请国别(地区):
世界知识产权组织国际局
年份:
2012
代理人:
摘要：
The present disclosure provides a series of compounds which exhibit isoform selective inhibition of GRP94, a homologue of Hsp90 that is localized to the endoplasmic recticulum. Through GRP94 inhibition, these compounds are likely to manifest anti-cancer, anti-inflammatory, anti-metastasis, and immunosuppressive activities, as well as utility in the treatment of neurodegenerative diseases, and diabetes.
