A kind of argentiferous tissue dressing offer antimicrobial properties, wound location are disclosed. In some embodiments, tissue dressing may include that there is wound-contacting layer base material to be coated with tacky hydrophobic silicone material, and-comprising being dispersed in silicone material. Various substrates material can be coated, with organosilicon material have various amounts viscosity, which can be to provide anti-microbial property, when tissue dressing is positioned to and rumour site.