< Topic >As for the nervous denaturation disease such as the Alzheimers disease, old age dementia, brain blood vessel characteristic dementia and the parkinsons disease, as for pathogenesis it differs, but each of them points to the symptom which displays obstacle in memory acknowledgment with the failure of the neuro network. Even from a state where obstacle of the neuro network is already advancing vis-a-vis the disease which does not have these effective cures, the Chinese medicine prescription to which the remedy which can bring close nervous function normally is required, uses for this remedy is developed.SolutionsIn the culture nerve cell, a state where decrease of atrophy of the axis cylinder and dendrite, the number of front synapses and the number of rear synapses is displayed was produced. By the fact that you deal with in the nerve cell of this state, the Chinese medicine prescription which can reset neurite and the synapse of the nerve cell to normal state was searched, 37 carrot and/or the carrot, yellow , the Chinese medicine prescription which consists of the extract of the iris and the the fact that it is useful as a neuro network reconstruction medicine was discovered.< Selective figure >Figure 1【課題】アルツハイマー病、老年痴呆、脳血管性痴呆、パーキンソン病などの神経変性疾患は、病因は異なるがいずれも神経回路網の破綻により、記憶・認知に障害を呈する症候を指す。これら有効な治療法の無い疾患に対し、既に神経回路網の障害が進行している状態からでも、神経機能を正常に近づけることのできる治療が求められており、この治療に用いる漢方処方を開発する。【解決手段】培養神経細胞において、軸索と樹状突起の萎縮、前シナプス数と後シナプス数の減少を呈する状態を作製した。この状態の神経細胞に処置することで、神経細胞の神経突起とシナプスを正常状態に戻すことのできる漢方処方を探索し、三七人参および/または人参、黄耆、菖蒲、茯苓の抽出物からなる漢方処方が神経回路網再構築剤として有用であることを見出した。【選択図】図1
