The invention disclosed in this patent relates to an improved process for the preparation of therapeutically active (1R, 2S)-Methoxamine, its salts and stereo isomers with high chiral purity. The (1R, 2S)-Methoxamine, prepared by the process of the present invention has wide applications as a pressor agent, as a vasoconstrictor, as a nasal decongestant, in ophthalmology and in the treatment of faecal incontinence.