In certain embodiments, the present invention is directed to a solid controlled release dosage form comprising: a core comprising a first portion of an opioid analgesic dispersed in a first matrix material； and a shell encasing the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material； wherein the amount of opioid analgesic released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37 C.於某些體系中，本發明針對包含下列之固態控釋劑量型：核心，其包含分散在第一基質材料中之第一部分類鴉片鎮痛藥；外殼，其包封該核心且包含分散在第二基質材料中之第二部分類鴉片鎮痛藥；其中在USP裝置1(籃法)中，在37℃、100 rpm下，於900毫升不含酶之模擬胃液(SGF)中藉由活體外溶離試驗測量時，在8至24小時之間與經過的時間成比例地從該劑量型釋出20%以內的類鴉片鎮痛藥。
