MACDONALD, Lynn,MCWHIRTER, John,GURER, Cagan,MEAGHER, Karolina A.,MURPHY, Andrew J.
申请号：
LT12783456
公开号：
LT2627773T
申请日:
2012.10.17
申请国别(地区):
LT
年份:
2017
代理人:
摘要：
Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human V H gene segment, a plurality of human D H gene segments and a plurality of J H gene segments. Methods for making antibody sequences that bind an antigen ( e.g ., a viral antigen) are provided, comprising immunizing a mouse with an antigen of interest, wherein the mouse comprises a single human V H gene segment, a plurality of human D H gene segments and a plurality of J H gene segments, at the endogenous immunoglobulin heavy chain locus.
