BUROVA, ELENA,MUJICA, ALEXANDER O.,LAI, KA-MAN VENUS,MURPHY, ANDREW J.
申请号：
CA2951278
公开号：
CA2951278A1
申请日:
2015.06.19
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Pdcd1 gene so that said non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
