The present invention provides hydroxygenkwanin nanoparticles, comprising hydroxygenkwanin and a stabilizer, wherein the mass ratio of the hydroxygenkwanin to the stabilizer is 1:0.02-1:10. The present invention further provides a preparation method for the hydroxygenkwanin nanoparticles, and application thereof in the preparation of anti-inflammatory drugs, antioxidant drugs, cardiovascular and cerebrovascular protection drugs, neuroprotection drugs, immunomodulation drugs, and anti-tumor drugs. The hydroxygenkwanin nanoparticles discovered in the present invention can keep stable and de-agglomerated in artificial gastrointestinal fluid and plasma, and are suitable for not only oral administration but also intravenous injection. In vitro cytotoxicity experiments show that the hydroxybumin nanoparticles exhibit a much higher tumor cell inhibition rate than hydroxygenkwanin DMSO solution. The hydroxybumin nanoparticles can be prepared into an oral preparation, an injection preparation, an inhalation preparation, and an external preparation as basic dosage forms for clinical applications, and after intravenous administration, can exhibit higher antitumor properties than intragastric administration. The hydroxybumin nanoparticles have better safety.La présente invention concerne des nanoparticules d'hydroxy-genkwanine, comprenant l'hydroxy-genkwanine et un stabilisant, le rapport en masse de l'hydroxy-genkwanine au stabilisant étant de 1 : 0,02-1 : 10. La présente invention concerne en outre un procédé de préparation de nanoparticules d'hydroxy-genkwanine, et leur application dans la préparation de médicaments anti-inflammatoires, de médicaments antioxydants, et de médicaments pour la protection cardiovasculaire et cérébrovasculaire, de médicaments pour la neuroprotection, de médicaments pour l'immunomodulation et de médicaments antitumoraux. Les nanoparticules d'hydroxy-genkwanine découvertes dans la présente invention peuvent rester stables et désagglomérées dans un
