3- (1- {3- [5- (1-Methyl-piperidin-4-ylmethoxy) -pyrimidin-2-yl] -benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl)- A novel polymorph of benzonitrile hydrochloride and its preparation
Compounds of the present invention concern 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The compound, 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile, has the following structural formula: The hydrochloride solvates and crystalline modifications thereof according to the invention are useful for treatment of physiological and/or pathophysiological conditions, such as cancer, that are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, especially Met-kinase. The present invention further relates to processes of manufacturing these crystalline modifications.本発明は、３－（１－｛３－［５－（１－メチル－ピペリジン－４－イルメトキシ）－ピリミジン－２－イル］－ベンジル｝－６－オキソ－１，６－ジヒドロ－ピリダジン－３－イル）－ベンゾニトリルの塩酸塩溶媒和物およびその結晶変態に関する。本発明はさらに、これらの結晶変態を製造する方法と、キナーゼのシグナル伝達の阻害、調節および／またはモジュレーションにより、特定するとチロシンキナーゼの阻害により起因、媒介および／または伝播される生理学的および／または病態生理学的状態、例えば、癌などの病態生理学的状態を治療および／または予防する際のそれらの使用とに関する。
