Patrick J. Ahl;Michael J. Caulfield;Jayme L. Cannon;Jeffrey T. Blue
发明人:
Michael J. Caulfield,Patrick J. Ahl,Jeffrey T. Blue,Jayme L. Cannon
申请号：
US13577810
公开号：
US20120301502A1
申请日:
2011.02.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a multivalent immunogenic composition having 15 distinct polysaccharide-protein conjugates. Each conjugate consists of a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F or 33F) conjugated to a carrier protein, preferably CRM197. The immunogenic composition, preferably formulated as a vaccine on an aluminum-based adjuvant, provides broad coverage against pneumococcal disease, particularly in infants and young children.
