HORNBERGER, Keith,MEYERS, Kenneth Michael,NEMOTO, Peter Allen,SURPRENANT, Simon,YU, Hui
申请号：
PE0007102017
公开号：
PE06962017A1
申请日:
2015.10.14
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to compounds derived from 3 - (2,3 Dihydro 1,4 - benzodioxin pyridine - 2 - il) of formula (i) wherein R1 is - CN, - C (o) NH2 or - C (o) NH (CH3) R2 is - - R4 (X), where X is a Link, - CH2 - or - O - H R4 is C1 - C3 alkyl, optionally substituted, halogen,Among others R3 is H or alkyl, optionally substituted with C1 - C3 - Oh and R2 and R3 together form a Ring of five members optionally substituted cycloalkyl merged with Oh.Preferred compounds are: acid amide 2 - [5 - (4 - hydroxy - tetrahydro - piran - 4-yl) pyridin-3-yl] - 2,3 Dihydro 1,4 - benzo [Dioxin] - 5 - carboxylic acid 2 - [4 - [2 - (dimethylamino) ethyl - 2 - oxo -] - 3 - pyridyl) - 2.3 - 1,4 - dihydro - 4 - benzodioxin carboxamide among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of aldosterone synthase (CYP11B2) being useful in the treatment of Diabetic Nephropathy and glomerulonephritisSE REFIERE A COMPUESTOS DERIVADOS DE 3-(2,3-DIHIDRO-1,4-BENZODIOXIN-2-IL)PIRIDINA DE FORMULA (I) DONDE R1 ES -CN, -C(O)NH2 O -C(O)NH(CH3) R2 ES -(X)-R4, EN DONDE X ES UN ENLACE, -CH2- U -O- R4 ES H, ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO, HALOGENO, ENTRE OTROS R3 ES H O ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO CON -OH O R2 Y R3 FORMAN JUNTOS UN ANILLO CICLOALQUILO FUSIONADO DE CINCO MIEMBROS OPCIONALMENTE SUSTITUIDO CON -OH. SON COMPUESTOS PREFERIDOS: AMIDA DE ACIDO 2-[5-(4-HIDROXI-TETRAHIDRO-PIRAN-4-IL)-PIRIDIN-3-IL]-2,3-DIHIDRO-BENZO[1,4]DIOXIN-5-CARBOXILICO 2-[5-[2-(DIMETILAMINO)-2-OXO-ETIL]-3-PIRIDIL]-2,3-DIHIDRO-1,4-BENZODIOXIN-5-CARBOXAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE ALDOSTERONA SINTASA (CYP11B2) SIENDO UTILES EN EL TRATAMIENTO DE NEFROPATIA DIABETICA, GLOMERULONEFRITIS
