The present invention relates to a high-intensity focused ultrasound device, and more specifically, to a high-intensity focused ultrasound device which has a structure changed so as to enable a disposable separable cartridge to be attached and detached, and which enables a doctor, who is the person performing a procedure, to obtain, through a scanning unit of a transducer for ultrasonic conversion, coordinates of a skin tissue of a subject undergoing the procedure, thereby allowing for an accurate procedure point to be checked in real time, thus allowing for a procedure to be performed on an accurate point on a skin tissue, without repeated procedures. The present invention relates to a high-intensity focused ultrasound device comprising a hand piece comprising: a hand piece body electrically connected by a wire to a freely movable moving body; and a separable cartridge disposably coupled to the hand piece body. The hand piece body comprises: a laser generator which fractionally transfers energy so as to facilitate the synthesizing of collagen; a transducer for ultrasonic conversion which receives electrical energy that has been impedance-matched by going through the processes of frequency generation and power amplification, converts the electrical energy into high-intensity focused ultrasound and irradiates same, or which receives reflected ultrasound; and an X-Y reflection mirror which undergoes in parallel a forward/backward movement and a tilting movement inside the hand piece body, and consecutively forms HIFU foci in a single row, or consecutively forms HIFU foci in a plurality of rows, or consecutively forms foci in a circular shape; a cooling device which supplies cooling gas to the separable cartridge; and a zoom-in device which zooms-in an image formed by the reflected ultrasound. The separable cartridge comprises: a cooling passage which enables cooling gas to be injected and to flow on the bottom surface of the separable cartridge, thereby lowering the t