HOWARD, Philip Wilson,THURSTON, David Edwin,RAHMAN, Khondaker Mirazur,TAYLOR, Peter William
申请号：
GBGB2013/051097
公开号：
WO2013/164592A1
申请日:
2013.04.30
申请国别(地区):
GB
年份:
2013
代理人:
摘要：
A compound of formula (I) or a salt or solvate thereof, wherein the dotted double bond indicates the presence of a single or double bond between C2 and C3； R2 is selected from -H, -OH, =O, =CH2, -CN, -R, OR, halo, dihalo, =CHR, =CHRR', -O- SO2-R, CO2R and COR； R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn and halo； where R and R' are independently selected from optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl groups； R10 and R11 either together form a double bond, or are selected from H and QRQ respectively, where Q is selected from O, S and NH and RQ is H or C1-7 alkyl or H and SOxM, where x is 2 or 3, and M is a monovalent pharmaceutically acceptable cation； A is selected from (A1), (A2), (A3), (A4) or (A5) where X1 and Y1 are selected from: CH and NH； CH and NMe； N and NMe； CH and S； N and S； N and O； and CH and O, respectively； X2 and Y2 are selected from: CH and NH； CH and NMe； N and NMe； CH and S； N and S； N and O； and CH and O, respectively； Z1 is selected from O and S； Z2 is selected from CH and N； F is selected from a single bond and –(E-F1)m-； each E is independently selected from a single bond, and –C(=O)-NH-； each F1 is independently a C3-20 heteroarylene group； m is 1, 2 or 3； G is selected from hydrogen, C1-4alkyl, -C(=O)-O-C1-4alkyl, -(CH2)n-C3-20 heterocycloalkyl, and –O-(CH2)n-C3-20 heterocycloalkyl group； each n is 0-4； provided that A2 is not A2', where X1 and Y1 of A2' are selected from: CH and NMe； COH and NMe； CH and S； N and NMe； N and S, respectively； and provided that A3 is not A3', where X2 and Y2 of A3' are selected from: CH and NMe； COH and NMe； CH and S； N and NMe； N and S, respectively； B is either a single bond or (B1), where X and Y of B1 are selected from: CH and NMe； COH and NMe； CH and S； N and NMe； N and S, respectively； and R1 is C1-4 alkyl.L'invention porte sur un composé de formule (I) ou un sel ou solvate de celui-ci, dans laquelle formule la double liaison en pointillé indique la p
