COOK II JAMES H,MCDONALD IVAR M,KING DALTON,OLSON RICHARD E,WANG NENGHUI,IWUAGWU CHRISTIANA I,ZUSI F. CHRISTOPHER,MACOR JOHN E
申请号：
NZ60024009
公开号：
NZ600240A
申请日:
2009.10.29
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
600240 The disclosure provides quinuclidine compounds of formula I their sterio isomers, and including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the alpha-7 nicotinic acetylcholine receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders. Compounds of the disclosure include: (R)-N-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-4H-1&rsquo；-azaspiro[oxazole-5,3&rsquo；-bicyclo[2.2.2]5 octan]-2-amine, (R)-N-(3,4&rsquo；-Bipyridin-2&rsquo；-yl)-4H-1&rsquo；-azaspiro[oxazole-5,3&rsquo；-bicyclo[2.2.2]octan]-2-amine, And (3R)-N-(6-chloro-5-bromopyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5&rsquo；-4H-1,3-oxazole]-2&rsquo；-amine
