IVAN LEO PINTO,SHAHZAD SHAROOQ RAHMAN,NEVILLE HUBERT NICHOLSON
申请号：
MYPI 20050527
公开号：
MY148937A
申请日:
2005.02.14
申请国别(地区):
MY
年份:
2013
代理人:
摘要：
THE PRESENT INVENTION PROVIDES THERAPEUTICALLY ACTIVE COMPOUNDS WHICH ARE XANTHINE DERIVATIVES, PROCESSES FOR THE MANUFACTURE OF SAID DERIVATIVES, PHARMACEUTICAL FORMULATIONS CONTAINING THE ACTIVE COMPOUNDS AND THE USE OF THE COMPOUNDS IN THERAPY, PARTICULARLY IN THE TREATMENT OF DISEASES WHERE UNDER-ACTIVATION OF THE HM74A RECEPTOR CONTRIBUTES TO THE DISEASE OR WHERE ACTIVATION OF THE RECEPTOR WILL BE BENEFICIAL, HAVING THE FORMULA (II): WHEREIN R¹ IS SELECTED FROM: HYDROGEN AND C₁₋₄ ALKYL WHICH MAY BE OPTIONALLY SUBSTITUTED WITH ONE OR MORE GROUPS SELECTED FROM CN AND CF₃, R² IS SELECTED FROM: C₂-₁₀ UNSUBSTITUTED ALKYL, C₁-₁₀ ALKYL SUBSTITUTED WITH ONE OR MORE GROUPS SELECTED FROM FLUORINE AND CN, C₅ ALKENYL, UNBRANCHED C₄ ALKENYL, AND C₁-₄ ALKYL SUBSTITUTED WITH CYCLOALKYL, AND R³ IS SELECTED FROM HALOGEN AND CN.
