具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之烷基衍生物农业专利-农业专业知识服务系统

发明人:: VIRGILI-BERNADO, MARINA,维尔吉利　贝尔纳多　马琳娜,維爾吉利　貝爾納多　馬琳娜,ALONSO-XALMA, MONICA,阿隆索　哈尔马　摩尼卡,阿隆索　哈爾馬　摩尼卡,ALEGRET-MOLINA, CARLOS,阿莱格雷特　莫利纳　卡洛斯,阿萊格雷特　莫利納　卡洛斯,ALMANSA-ROSALES, CARMEN,阿曼萨　罗沙勒斯　卡门,阿曼薩　羅沙勒斯　卡門,GARC,维尔吉利贝尔纳多马琳娜,維爾吉利貝爾納多馬琳娜,阿隆索哈尔马摩尼卡,阿隆索哈爾馬摩尼卡,阿莱格雷特莫利纳卡洛斯,阿萊格雷特莫利納卡洛斯,阿曼萨罗沙勒斯卡门,阿曼薩羅沙勒斯卡門

摘要：: The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.本發明係關於具有針對西格馬(sigma)(σ)受體及μ-類鴉片受體之雙重藥理學活性的化合物，且更特定言之，係關於具有此藥理學活性之二氮雜螺十一烷化合物；該等化合物之製備方法；包含其之醫藥組成物；及其在療法，特定言之，治療疼痛中之用途。