This invention relates to methods for enhancing an image by expanding the color contrast of the image presented to a wider range of colors that is optimized for the item sought to be viewed. The method also increases contrast of an image or a portion of an image for example an in vivo image captured by an autonomous in vivo device. A user interface with a display provides the user with the option of viewing selected images captured by the in-vivo imaging device in either regular view or in a color enhanced view to enable more distinct viewing of the selected images.