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Cyclic purine dinucleotides as regulators of STING
专利权人:
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド
发明人:
ジェリー、リロイ、アダムス,ケビン、ジェイ.ダフィー,イキアン、リアン,ケビン、ジェイ.ダフィー
申请号:
JP2017560295
公开号:
JP6411676B2
申请日:
2016.12.01
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
A compound of Formula (VI) wherein R 58 and R 59 are independently selected from: H, CH 2 OC(O)R 57 , CH 2 OCO 2 R 57 , CH 2 CH 2 SC(O)R 57 , and CH 2 CH 2 SSCH 2 R 57 ; provided that at least one of R 58 and R 59 is not H; R 56 is F; X 51 O; X 52 is O. Pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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