The United States of America, as represented by the Secretary, Dept. of Health and Human Services;Loyola University of Chicago
发明人:
Richard W. Childs,Michael I. Nishimura,Elena A. Cherkasova
申请号：
US16313712
公开号：
US20190231821A1
申请日:
2017.06.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are T cell receptors (TCRs) capable of binding an antigen expressed by renal cell carcinoma cells. In some examples, the TCRs include an α chain (such as SEQ ID NO: 2) and a β chain (such as SEQ ID NO: 3). Also disclosed herein are vectors including nucleic acids encoding the disclosed TCR α and/or β chains. Further disclosed are modified T cells expressing the TCRs. In some examples, the modified T cells are prepared by transducing T cells with a vector including nucleic acids encoding the TCR α chain and the TCR β chain. In some embodiments, methods include treating a subject with RCC, by obtaining a population of T cells, transducing the population of T cells with a vector including a nucleic acids encoding the TCR α chain and the TCR β chain, and administering a composition comprising the modified T cells to the subject.
