Robert Zhao;Suzhou M-Conj Biotech Co., Ltd;Suzhou M-Conj Biotech Co.; Ltd
发明人:
Zhao, Robert Yongxin
申请号：
AU2015242213
公开号：
AU2015242213A1
申请日:
2015.07.12
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention relates to novel linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
