ROYAL CANCER HOSPITAL;THE INSTITUTE OF CANCER RESEARCH
发明人:
申请号：
IL27372720
公开号：
IL273727D0
申请日:
2020.03.31
申请国别(地区):
IL
年份:
2020
代理人:
摘要：
This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of the compounds in the treatment of conditions mediated by LOX and LOXL, for example cancer. In particular a LOX inhibitor such as the present compounds may be for use in the treatment of a cancer associated with EGFR. The present invention also contemplates the identification of biomarkers that predict responsiveness to a LOX inhibitor.
