PROBLEM TO BE SOLVED: To provide pharmaceutical compositions that can be used as anticancer agents, drug tolerant anti-cancer therapeutics, cancer recurrence inhibitors, cancer metastasis inhibitors, or postoperative adjuvant therapeutic agents which contain as an active ingredient a cell surface molecule that is specific to a Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) positive cancer stem cell with high proliferation potency and to a Lgr5 negative cancer stem cell with low proliferation potency, or an antibody to cell surface molecules thereof.SOLUTION: The present invention provides a pharmaceutical composition containing at least one antibody binding to a particular sequence of Lgr5.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】増殖能の高いロイシン-リッチ-リピート含有Gタンパク質共役受容体5（Lgr5）陽性癌幹細胞と増殖能の低いLgr5陰性癌幹細胞に特異的な細胞表面分子、またこれらの細胞表面分子に対する抗体を有効成分として含有する抗癌剤、薬剤抵抗性癌治療剤、癌再発抑制剤、癌転移抑制剤または術後アジュバント療法剤として使用できる医薬組成物の提供。【解決手段】Ｌｇｒ５の特定の配列に結合する少なくとも一つの抗体を含有する医薬組成物。【選択図】なし
