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СОСТАВ С СИМЕТИКОНОМ
专利权人:
ДИСФАР ИНТЕРНЭШНЛ Б.В. (NL)
发明人:
ВЕЛАДА Хосе Луис (NL),ДОШИ Хитешкумар Анилкант (IN),ТЕНДУЛКАР Анджали Раджеш (IN),СХИНДЕ Вики (IN)
申请号:
RU2014128604
公开号:
RU2014128604A
申请日:
2012.12.11
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A pharmaceutical composition comprising a mixture of simethicone, a powder of calcium phosphate and mannitol, and wherein simethicone is present in an amount of 1-60 wt.%, Of calcium phosphate powder is present in an amount of 20-70 wt.%, And mannitol present in an amount of 20-70 wt . kompozitsii.2%. Composition according to Claim. 1, wherein the mixture of simethicone, calcium phosphate powder and granular mannitol does not contain phosphate kaltsiya.3. Composition according to claim. 1 or 2, wherein the mixture consists essentially of simethicone, calcium phosphate powder and mannita.4. . Composition according to claim 1, wherein the weight ratio of mannitol to the powder of calcium phosphate is 1: 1 or greater than 1: 1.5. Composition according to claim 1, wherein the weight ratio of mannitol to calcium phosphate powder is in the range of 1: 1. to 7: 1.6. Composition according to claim 1, wherein the weight ratio of simethicone to calcium phosphate powder is in the range of 1:. 0.6 to 1: 2,2.7. Composition according to Claim. 1, which contains 10-20 wt.% Of simethicone, 20-50 wt.% Of calcium phosphate powder and 20-50 wt.% Mannita.8. Composition according to Claim. 1 further comprising an active ingredient selected from the group consisting of loperamide, olanzapine, risperidone, loratadine, hydrochlorothiazide, donepezil hydrochloride, ondansetron, clonazepam, clozapine, mitrazapina, okskarbazapina, tramadol, cetirizine, lamotrizina, alprazolam, rizatriptan, zolmitriptan, montelukast and desloratadine paratsetamola.9. A composition according to claim. 8, wherein the active ingredient is loperamid.10. A composition according to claim. 9, where more than 80% of the active ingredient is released in 30 minutes at a temperature of 37 ° C and a rotation speed of 75 rev / min in an aqueous solution having a pH in the range from 1 to 7,0.11. A pharmaceutical composition comprising 55-95 wt.% Simethicone mixture powder of calcium phosphate and mannitol, wherein the m
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