Fundación Centro Nacional de Investigaciones Oncologicas Carlos III
发明人:
Joaquín Pastor Fernández,Rosa María Álvarez Escobar,Rosario Concepción Riesco Fagundo,Ana Belén García García,Antonio Rodríguez Hergueta,Jose Ignacio Martín Hernando,Carmen Blanco Aparicio,David Álvar
申请号：
US15006755
公开号：
US09808466B2
申请日:
2016.01.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
