Andrew J. Murphy,Alexander O. Mujica,Ka-Man Venus Lai,Sokol Haxhinasto,Zaruhi Hovhannisyan
申请号：
US16512949
公开号：
US20200015462A1
申请日:
2019.07.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This disclosure relates to genetically modified rodent animals and rodent models of human diseases. More specifically, this disclosure relates to genetically modified rodents whose genome comprises a humanized Il1rl2 gene (coding for the IL1rl2 subunit of the IL-36R protein) and human IL-36α, β and γ ligand genes. The genetically modified rodents disclosed herein display enhanced skin and intestinal inflammation as a preclinical model of psoriasis and IBD, respectively, and serve as a rodent model of human DITRA disease.
