Tracey C. Fleischer,Daniel M. Cimbora,Jeffrey S. Flick,Andrew D. Gassman,Vijay R. Baichwal,Damon I. Papac
申请号：
US14539720
公开号：
US20160367541A1
申请日:
2014.11.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to methods of treating diseases, particularly cancers, that respond favorably to the inhibition of Nicotinamide phosphoribosyltransferase (Nampt) it also relates to therapeutic methods that utilize Nampt inhibitors in combination with NAD biosynthesis precursors to intentionally kill cancer cells while limiting or minimizing toxicity to normal host cells and it relates to methods of identifying cancers that will be most responsive to treatment with Nampt inhibitors, particularly when administered in combination with nicotinic acid.
