RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY;성균관대학교산학협력단
发明人:
CHO, JAE YOUL,조재열,HONG, SUNG YOUL,홍성렬,YANYAN YANG,양얀얀,KIM, HAN GYUNG,김한경,KIM, JI HYE,김지혜,KIM, EUN JEE,김은지
申请号：
KR1020120083743
公开号：
KR1020140017199A
申请日:
2012.07.31
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a pharmaceutical composition, a food composition, and a cosmetic composition for anti-inflammation, containing 2,3-Bis[(2-hydroxyethyl)thio]-1,4-naphthoquinone as an active ingredient. The composition of the present invention fundamentally reduces the generation of TNF-&alpha；, PGE_2, and NO, which are inflammation-related factors, from the transcriptional stage, thereby exhibiting excellent anti-inflammatory effect. Further, the composition of the present invention can be safely applied to medicines, food, and cosmetics since it does not exhibit cytotoxicity in spite of treatment at high concentration. Accordingly, the composition of the present invention is expected to be significantly applied as an anti-inflammatory agent.본 발명은 2,3-Bis[(2-hydroxyethyl)thio]-1,4-naphthoquinone을 유효성분으로 함유하는 항염증용 약학적 조성물, 식품 조성물 및 화장료 조성물에 관한 것이다. 본 발명의 조성물은 염증관련 인자인 TNF-α, PGE2, NO의 생성을 전사 단계에서부터 근본적으로 감소시켜 우수한 소염 효과를 가진다. 또한 고농도로 처리한 경우에도 세포독성을 보이지 않아서 의약품 , 식품 및 화장료에 안전하게 적용할 수 있다. 따라서 항염증제로서 중요하게 응용될 수 있을 것으로 기대된다.
