Systems and methods for pre-stationing and regulating access to emergency medical supplies, by a bystander. The system includes a supply box having medical supplies, a processor, a network interface in communication with the processor, and a keycode receiving device for receiving a keycode associated with the supply box, as well as control software in communication with the network interface of the supply box and at least one database for storing the keycode associated with the supply box. The method includes steps for ultimately enabling the bystander to access the medical supplies for use in response to the emergency.