VARIANTS DE REGION FC AVEC DES PROPRIETES DE LIAISON DE FCRN MODIFIEES

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

SCHLOTHAUER, TILMAN

申请号：

CA2931979

公开号：

CA2931979A1

申请日:

2015.01.12

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain and an immunoglobulin CH3-domain, wherein i) the first and the second polypeptide comprise the mutations H310A, H433A and Y436A, or ii) the first and the second polypeptide comprise the mutations L251D, L314D and L432D, or iii) the first and the second polypeptide comprise the mutations L251S, L314S and L432S.

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