Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegrens syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.Linvention porte sur des hétéroaryles bicycliques substitués et sur des compositions les contenant, pour le traitement dune inflammation générale, de larthrite, de maladies rhumatoïdes, dostéoarthrite, de troubles inflammatoires de lintestin, de troubles inflammatoires de lœil, de troubles inflammatoires ou instables de vessie, du psoriasis, de troubles de la peau associés à des composantes inflammatoires, détats inflammatoires chroniques, comprenant, mais non nécessairement restreints à, des maladies auto-immunes telles que le lupus érythémateux systémique (SLE), la myasthénie grave, larthrite rhumatoïde, lencéphalomyélite disséminée aiguë, la purpura thrombocytopénique idiopathique, la sclérose en plaques, le syndrome de Sjögren et lanémie hémolytique auto-immune, les états allergiques comprenant toute les fo
