Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegrens syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.Cette invention concerne des hétéroaryles bicycliques substitués et des compositions les contenant, pour traiter linflammation générale, larthrite, les maladies rhumatismales, larthrose, les troubles inflammatoires intestinaux, les troubles inflammatoires oculaires, les affections inflammatoires ou dinstabilité de la vessie, le psoriasis, les affections cutanées avec composantes inflammatoires, les affections inflammatoires chroniques comprenant, entre autres, les maladies auto-immunes telles que le lupus systémique érythémateux (SLE), la myasténie grave, la polyarthrite rhumatoïde, lencéphalomyélite disséminée aiguë, le purpura thrombocytopénique idiopathique, la sclérose en plaques, le syndrome de Sjoegren et lanémie hémolytique auto-immune, et les affections allergiques comprenant toutes les formes de lhyper
