The prosthesis (1) for enterostomy patients comprises: —a tubular element (2) of elongated shape and insertable substantially to size inside of a stoma (3) made on the abdominal wall (4) of a patient —a first obstruction means (8) to obstruct at least one area of the stoma (3), associated with a first end (6) of the tubular element (2) and movable between a restricted configuration (9) and an enlarged configuration (10) to allow the insertion/extraction into/from the stoma (3) respectively, and to prevent leakage of feces from the stoma itself —a first through duct (13) made on the tubular element (2), communicating with the first obstruction means (8) and having valve means (14) connectable to forced introduction/extraction means (15) of a fluid into/from the first obstruction means (8) —a second through duct (19) made on the tubular element (2), communicating with the inside of the stoma (3) and having filtering means (20) for the outflow of gases from the stoma itself and —an external retaining element (11) associated with a second end (7) of the tubular element (2) opposite to the first end (6) and able to cooperate with at least one portion of the abdominal wall (4) and having at least two through holes (16, 21) arranged at the first duct (13) and the second duct (19) in which at least one of the tubular element (2) and the retaining element (11) is made at least partially of a flexible material.
