This invention offers the screening manner of the active ingredient of the anti- C die hepatitis virus constituent which has the process which chooses the material which inhibits C die hepatitis virus infection prevention or breeding suppression manner, and the PA28 gene expression or the function which include the process which prescribes the anti- C die hepatitis virus constituent and the aforementioned constituent which include the material which suppresses the PA28 gene expression or function to the subject.本発明はPA28γ遺伝子の発現又は機能を抑制する物質を含む抗C型肝炎ウイルス組成物、前記組成物を被験体に投与する工程を含むC型肝炎ウイルス感染予防又は増殖抑制方法、並びに、PA28γ遺伝子の発現又は機能を阻害する物質を選択する工程を備えた抗C型肝炎ウイルス組成物の有効成分のスクリーニング方法を提供する。
