Refers to a Pharmaceutical composition comprising effective amounts of (a) aflibercept in combination with folinic acid (b) (c) 5-fluorouracil (5-fu), irinotecan, and (d) to take simultaneous, Sequential or sparingly. It also relates to a kit comprising Pharmaceutical compositions of these Active principles in separate containers.Said composition is useful in the treatment of metastatic colorectal cancer (CRC)SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE CANTIDADES EFICACES DE: A) AFLIBERCEPT EN COMBINACION CON B) ACIDO FOLINICO C) 5-FLUOROURACILO (5-FU) Y D) IRINOTECANO, QUE SE ADMINSTRAN DE MODO SIMULTANEO, SECUENCIAL O DE MANERA ESPACIADA. TAMBIEN SE REFIERE A UN KIT QUE COMPRENDE COMPOSICIONES FARMACEUTICAS DE DICHOS PRINCIPIOS ACTIVOS EN RECIPIENTES SEPARADOS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DEL CANCER COLORRECTAL (CRC) METASTASICO
