A Pharmaceutical composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinotecan (FOLFIRI) useful for the treatment of Colorectal Cancer (CRC).Una composición farmacéutica que comprende aflibercept, ácido folinico, 5-fluorouracilo (5-FU) e irinotecano (FOLFIRI) útil para el tratamiento del cancer colorrectal (CRC).