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2-Pyridone derivatives as neutrophil elastase inhibitors and their use
专利权人:
ASTRAZENECA AB
发明人:
ANDERSSON, MARJANA,HANSEN, PETER,LOENN, HANS,NIKITIDIS, ANTONIOS,SJOELIN, PETTER
申请号:
ES04775438
公开号:
ES2448465T3
申请日:
2004.09.15
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula (I) ** Formula ** wherein: Y represents CR3 or N; R1 represents H or C1 to 6 alkyl; R2 represents phenyl or a five or six membered heteroaromatic ring containing from 1 to 4 heteroatoms selected independently from O, S and N; said aromatic ring being optionally substituted with 1 to 3 substituents independently selected from OH, halogen, C 1 to 6 alkyl, C1 to 6 alkoxy, NR58COR50, COOR51, COR52, CONR53R54 and NR47R4810, said alkyl being optionally further substituted with OH, C1 to 6 alkoxy , CN or CO2R49; R47 and R48 independently represent H, C1 to 6 alkyl or C2 to 6 alkanoyl; R3 represents H or F; G1 represents phenyl or a five or six membered heteroaromatic ring containing 1 to 3 heteroatoms selected independently from O, S and N; R5 represents H, halogen, C1 to 6 alkyl, CN, C1 to 6 alkoxy, NO2, NR14R15, C1 to 3 alkyl substituted by one or more atoms of F or C1 to 3 alkoxy substituted by one or more F atoms; R14 and R15 independently represent H or C1 to 3 alkyl; said alkyl being optionally further substituted with one or more F atoms; n represents an integer 1, 2 or 3 and when n represents 2 or 3, each group R5 is independently selected: R4 represents H or C1 to 6 alkyl; said alkyl being optionally further substituted by OH or C1 to 6 alkoxy; or R4 and L are joined together such that the group -NR4L represents a 5- to 7-membered azacyclic ring that optionally incorporates an additional heteroatom selected from O, S and NR16; L represents a bond, O, S (O) p, NR29 or C1 to 6 alkyl; said alkyl optionally incorporating a heteroatomose selected from O, S and NR16, and said alkyl is optionally further substituted by OH or OMe; G2 represents a monocyclic ring system selected from: i) phenyl or phenoxy, ii) a 5- or 6-membered heteroaromatic ring containing one to three heteroatoms independently selected from O, S and N.Un compuesto de fórmula (I)**Fórmula** en donde: Y representa CR3 o N; R1 representa H o alquilo C1 a 6; R2 representa fenilo o un
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