A sterile drape (10) maintains a sterile field during use of a flat panel touchscreen (22) during diagnostic and/or therapeutic procedures. The drape comprisessterile front (50) and rear (52) sheets formed from a thin layer of a transparentmaterial that accommodates the transmission of tactile pressure. The rear sheetmay comprise a folded extension of the front sheet along the top edge (54), withthe sheets bonded along the sides. A bottom opening between the front and the rearsheets allows cooling air to enter, and at least one ventilation opening (68)is near the top.