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NEW VACCINE COMPOSITIONS INCLUDING SAPONIN-CONTAINING ADJUVANTS
专利权人:
МЕРИАЛ ЛИМИТЕД
发明人:
ДЕТРА Ноэль Жозеф Франсуа,РИГО Гийом
申请号:
RU2012113814
公开号:
RU2012113814A
申请日:
2010.09.09
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A vaccine composition comprising an injectable oil-in-water emulsion (M / B) comprising (i) an aqueous solution comprising at least one immunogen; (ii) an aqueous solution comprising a hydrophobic ionic surfactant (iii ) if necessary, an aqueous solution comprising aluminum hydroxide (iv) mineral oil; (v) a nonionic lipophilic surfactant; (vi) a nonionic hydrophilic surfactant having a high hydrophilic lipophilic balance (HLB) of 13 to 40; and (vii) a non-ionic hydrophilic surfactant having a low hydrophilic-lipophilic balance (HLB) value of from 9 to 13.2. The composition of claim 1, wherein the hydrophilic ionic surfactant is saponin, and wherein the concentration of saponin is from about 0.35 mg / dose to about 3 mg / dose, and where the concentration of aluminum hydroxide is from about 0% to about 1 % (w / v) 3. The composition according to claim 2, in which a non-ionic hydrophilic surfactant with high HLB is present in a concentration of 0.1-1.5%, expressed as the ratio of mass to volume of the emulsion (mass./vol.), And where the percentage of surface the active substance is from about 4% to about 8% w / v. 4. The composition according to claim 2, wherein the non-ionic hydrophilic surfactant with low HLB is present in a concentration of 1-8%, expressed in weight per volume of the emulsion (w / v). The composition according to claim 2, wherein the non-ionic lipophilic surfactant is present in a concentration of 0.1-2.5%, expressed as a mass per volume of the emulsion (w / v). The composition according to claim 2, in which the mineral oil is present in a concentration of 20% -40% (vol./vol.)1. Вакцинная композиция, включающая инъецируемую эмульсию масло-в-воде (М/В), включающую(i) водный раствор, включающий, по меньшей мере, один иммуноген;(ii) водный раствор, включающий гидрофобное ионное поверхностно-активное вещество(iii) при необходимости водный раствор, включающий гидроксид алюминия(iv) минеральное масло;(v) неионное липофильное поверхностно-активное вещ
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