KELLENBERGER, JOHANNES LAURENZ,DREIER, JUERG,REINELT, STEFAN BERNHARD
申请号：
CA2713776
公开号：
CA2713776C
申请日:
2009.02.09
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention relates to macrolide compounds of formula (1),the use of saidcompounds as medicaments, in particularfor the treatment or prevention of inflammatory and allergic diseases,pharmaceutical compositions containing said compoundsand to processes for their preparation. The invention relates in particular tomacrolide compounds with anti-inflammatoryactivity mediated primarily through inhibition of phosphodiesterase 4 (PDE4)which makes them useful for the treatment and/orprevention of inflammatory and allergic diseases such as chronic obstructivepulmonary disease (COPD), asthma, rheumatoidarthritis, atopic dermatitis or inflammatory bowel disease or proliferativediseases such as cancer.
