JOHANNES AEBI,WENMING CHEN,BERND KUHN,YONGFU LIU,RAINER E. MARTIN,KURT AMREIN,BENOIT HORNSPERGER,DONGBO LI,HANS P. MAERKI,ALEXANDER V. MAYWEG,XUEFEI TAN,LISHA WANG,JUN WU,MINGWEI ZHOU
申请号：
ARP140102071
公开号：
AR096423A1
申请日:
2014.05.26
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: the compound of equation (1), wherein R1,R2,R3 and r830808 were selected from h, tar and cyclopentadiene respectively； r83099；R8310,R831111 and r8313 are independently selected from h, hydrocarbon, halogen and hydrogen Xi； r831222 and R1 are added together to form - ch832222-ch8322；R1 8304es h or R1 830404 combined with R1 to form - (CH 832222) 695；A es -C (O) - o -S (O) -B is - c-o-n；R² is alkyl, cycloalkyl or substituted heteroaryl, wherein substituted heteroaryl is substituted with one to three substituents independently selected from H, alkyl, cycloalkyl, hydroxy, alkoxy, cyano and halogen； R 3 is halogen, cyano, alkoxy or haloalkoxy； R¹⁴ is H, alkyl or halogen； m, n and p are independently selected between zero and 1； w is 1, 2 or 3； with the proviso that 2- [5- (1-acetyl-pyrrolidin-3-yl) -pyridin-3-yl] -5-chloro-3,3-dimethyl-2,3-dihydro-isoindole-1 is excluded -one and 2- (1-acetyl-1,2,3,4,5,6-hexahydro- [3,4] bipyridinyl-5-yl) -5-chloro-3,3-dimethyl-2,3- dihydro-isoindole-1-one； and pharmaceutically acceptable salts thereof.Reivindicación 1: Compuestos de fórmula (1) en la que R¹, R², R³ y R⁴ se seleccionan independientemente entre H, alquilo y cicloalquilo； R⁵, R⁶, R⁷ y R⁹ se seleccionan independientemente entre H, alquilo, halógeno e hidroxi； R⁸ y R¹¹ en conjunto forman -CH₂-CH₂； R¹⁰ es H o R¹⁰ y R¹¹ en conjunto forman -(CH₂)ʷ-； A es -C(O)- o -S(O)₂-； B es -C- o -N-； R¹² es alquilo, cicloalquilo o heteroarilo sustituido, en el que heteroarilo sustituido está sustituido con uno a tres sustituyentes seleccionados independientemente entre H, alquilo, cicloalquilo, hidroxi, alcoxi, ciano y halógeno； R¹³ es halógeno, ciano, alcoxi o haloalcoxi； R¹⁴ es H, alquilo o halógeno； m, n y p se seleccionan independientemente entre cero y 1； w es 1, 2 ó 3； con la condición de que se excluyan 2-[5-(1-acetil-pirrolidin-3-il)-piridin-3-il]-5-cloro-3,3-dimetil-2,3-dihidro-isoindol-1-ona y 2-(1-acetil-1,2,3,4,5,6-hexahidro-[3,4]bipiridinil-5-il)-5-cloro-3,3-dimetil-2,
