BUCHSTALLER, HANS-PETER,FINSINGER, DIRK,WIESNER, MATTHIAS,BURGDORF, LARS,AMENDT, CHRISTIANE,GRELL, MATTHIAS,SIRRENBERG, CHRISTIAN,ZENKE, FRANK
申请号：
ES04739891
公开号：
ES2380201T3
申请日:
2004.06.15
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Benzimidazole derivatives of formula I wherein R 6, R 7 are independently from each other H or A, A is independently selected from the group consisting of alkyl, alkoxy and alkoxyalkyl, R 8 is selected from a group consisting of H, A, cycloalkyl comprising 3 at 7 carbon atoms, Hal, CH2Hal, CH (Hal) 2, C (Hal) 3, NO2 and (CH2) nCN, R9 and R10 are independently selected from a group consisting of H, A, cycloalkyl comprising from 3 to 7 carbon atoms, Hal, CH2Hal, CH (Hal) 2, C (Hal) 3, NO2, (CH2) nCN, (CH2) nNR11R12, (CH2) nOR11, (CH2) nO (CH2) kNR11R12, (CH2) nCOOR12, (CH2) nCONR11R12, (CH2) nNR11COR13, (CH2) nNR11CONR11R12, (CH2) nNR11SO2A, (CH2) nSO2NR11R12, (CH2) nS (O) uR13, (CH2) nOC (O) R13, (CH2, 13) (CH2) nSR11, CH = N-OA, CH2CH = N-OA, (CH2) nNHOA, (CH2) nCH = N-R11, (CH2) nOC (O) NR11R12, (CH2) nNR11COOR12, (CH2) nN ( R11) CH2CH2OR13, (CH2) nN (R11) CH2CH2OCF3, (CH2) nN (R11) C (R13) HCOOR12, C (R13) HCOR12, (CH2) nN (R11) CH2CH2N (R12) CH2COOR12, (CH2) nN (R11) CH2CH2NR11R12, CH = CHCOOR11, CH = CHCH2NR11R12, CH = CHCH2NR11R12, CH = CHCH2OR13, (CH2) nN (COOR11) COOR12, (CH2) nN (CONH2) COOR11, (CH2) nN (CONH2 CONH2, (CH2) nN (CH2COOR11) COOR12, (CH2) nN (CH2CONH2) COOR11, (CH2) nN (CH2CONH2) CONH2, (CH2) nCHR13COR11, (CH2) nCHR13COOR11, (CH2) nCHR13CH2OR14, (CH2) (CH2) CH2) nNCO, where R11, R12 are independently selected from a group consisting of H, A, (CH2) mAr3 and (CH2) mHet, or in NR11R12 R11 and R12 form, together with the N atom to which they are attached, a heterocycle of 5, 6 or 7 atoms that optionally contain 1 or 2 additional heteroatoms, selected from N, O and S, R13, R14 are independently selected from a group consisting of H, Hal, A, (CH2) mAr4 and (CH2) mHet, Ar3, Ar4 are independently from each other aromatic hydrocarbon moieties comprising from 5 to 12 and, preferably, from 5 to 10 carbon atoms that are optionally substituted with one or more substituents, selected from a group po composed of A, Hal, NO2, CN, OR15, NR15R16, COOR15, CONR15R1
