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Oligonucleotide structure and gene expression control method
专利权人:
公立大学法人大阪市立大学
发明人:
立花 亮,田辺 利住
申请号:
JP2010519818
公开号:
JP5594838B2
申请日:
2009.07.09
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
Disclosed is an oligonucleotide structure which can distinguish between a normal cell and an abnormal cell such as a cancer cell and can act only in an abnormal cell. The oligonucleotide structure comprises three oligonucleotide chains, i.e., a trigger chain, an effector chain and a support chain, wherein each of the three oligonucleotide chains is bound to the other two chains so as to form a structure like a three-way joint, and wherein the trigger chain has a site capable of recognizing the sequences of other polynucleotide chains on the outside of a site that is bound to the support chain.
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