Provided is a method of selective activation for a magnetic nanoparticle having a magnetic vortex structure. The method of selective activation for a magnetic nanoparticle in accordance with an embodiment of the present disclosure includes providing a magnetic nanoparticle having a magnetic vortex structure; applying a first magnetic field to the magnetic nanoparticle so that the magnetic nanoparticle has a resonance frequency; and activating the magnetic nanoparticle by applying a second magnetic field having the resonance frequency to the magnetic nanoparticle.