A closure assembly structured for use with a female luer connector operative to indicate an attempted tampering or access thereto. A flow restrictor is movably and removably disposed within a housing and includes a male connector, such as a male luer connector, inserted in flow restricting engagement within an interior port of the female luer connector. An indicator member is removably connected within the housing and a drive assembly associated with both the flow restrictor and the housing is operable to dispose the male connector in flow restricting engagement within the female connector. Attempted removal of the closure assembly from the female connector will detach an indicator member from the housing and visually expose it, thereby indicating attempted access.
