The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.本發明關於特異結合組織因子途徑抑制劑(TFPI)並抑制其活性之抗體類及彼等之抗原結合片段。該等抗體類及片段可用於治療出血性病症並縮短凝血時間。