THE GOVERNMENT OF THE UNITED STATES OF AMERICA; AS REPRESENTED BY SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
SMITH, TODD G.,WU, XIANFU
申请号：
CA2814373
公开号：
CA2814373A1
申请日:
2011.10.18
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Described herein is a method of identifying a monoclonal antibody (or antigen- binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naive antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.
